WHY GENE THERAPY?
Exosomes are stable in the circulation, they escape the immune system instead of triggering it, they can cross the blood-brain-barrier, and therefore have the potential to mediate signaling over large distances in the body. They are an ideal non-immunogenic, safe, targeted and efficient vehicle for delivering a therapy payload.
The other delivery systems for therapeutics have significant deficiencies. Most of them are unable to target widespread cancer cells, they trigger the immune system and end up destroyed in the liver. The efficacy of conventional treatments is limited by their poor bioavailability, the resulting high dose requirements resulting in increased toxicity and cancer resistance to treatments. Consequently, there are ongoing efforts to develop new approaches for more effectively delivering therapies to cancer cells without harming the patient’s healthy cells.